Dynamic Tracking of Osteoblastic Cell Traction Force during Guided Migration
نویسندگان
چکیده
منابع مشابه
Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
Dendritic cells (DCs) are potent initiators of the adaptive immune response. Their trafficking from sites of inflammation to lymphoid tissue is essential to their function. Exactly how dendritic cells integrate multiple chemotactic cues to organize an accurate migratory path is not fully understood. We first characterize DC random motility (chemokinesis) on extracellular matrix proteins in the ...
متن کاملFriction-controlled traction force in cell adhesion.
The force balance between the extracellular microenvironment and the intracellular cytoskeleton controls the cell fate. We report a new (to our knowledge) mechanism of receptor force control in cell adhesion originating from friction between cell adhesion ligands and the supporting substrate. Adherent human endothelial cells have been studied experimentally on polymer substrates noncovalently c...
متن کاملDynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo
Cell migration and polarization is controlled by signals in the environment. Migrating cells typically form filopodia that extend from the cell surface, but the precise function of these structures in cell polarization and guided migration is poorly understood. Using the in vivo model of zebrafish primordial germ cells for studying chemokine-directed single cell migration, we show that filopodi...
متن کاملThe principles and biological applications of cell traction force microscopy
When a cell adheres to an underlying substrate, it exerts traction forces on the substrate to enable migration. The cell traction forces (CTFs) are also essential for controlling cell shape and maintaining cellular homeostasis. As such, CTF plays a vital role in many fundamental biological processes including morphogenesis, angiogenesis, metastasis, and tissue wound healing. Thus, a close exami...
متن کاملDistribution of Traction Forces and Intracellular Markers Associated with Shape Changes During Amoeboid Cell Migration
during migration, amoeboid cells perform a cycle of quasi-periodic repetitive events (motility cycle). the cell length and the strain energy exchanged with the substrate oscillate in time with an average frequency, f, on top of which are imposed smaller random fluctuations. the fact that a considerable portion of the changes in cell shape are due to periodic repetitive events enables the use of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Bioengineering
سال: 2017
ISSN: 1865-5025,1865-5033
DOI: 10.1007/s12195-017-0514-7